Expressive

rs11539148 - QARS1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

  • Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms - Unknown journal (n.d.) · Unknown authors · PubMed 30696823

    ABSTRACT: Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Serum uric acid levels High

    QARS1 C allele associated with increased serum urate; elevated urate is a gout risk factor and marker of metabolic dysfunction.

    Obtain baseline serum uric acid; repeat every 2-3 years or if gout symptoms develop.

Diet

  • High-purine foods Moderate

    Genetic variant increases serum urate; dietary purines amplify urate production and gout risk.

    Minimize organ meats, anchovies, high-fructose beverages; maintain consistent hydration.

Lifestyle

  • Schedule important work in morning hours Moderate

    QARS1 C allele associated with morning chronotype preference; aligning major activities with natural peak alertness hours optimizes performance.

    Schedule cognitively demanding tasks and meetings between 8am-noon; avoid evening shift work if possible.