rs115353340 - TTC34 - ACTRT2

Magnitude 2.2 · 1 study on file

Reported associations

• Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 34854908

  ABSTRACT: Key Points Question Are genetic variants associated with neuropathic pain (NP) susceptibility? Findings This genetic association study included a meta-analysis of 3 genome-wide association studies, with 4512 individuals with NP and 428 489 without, all with European descent, and identified a novel genome-wide significant locus at chromosome 12q23.1 near SLC25A3 and a suggestive locus at chromosome 13q14.2 near CAB39L. These mitochondrial phosphate carriers and calcium binding genes are expressed in tissues associated with the generation of NP, including the brain and dorsal root ganglia. Meaning These findings may provide a better understanding of genetic predisposition to NP, and this may inform the development of new treatment strategies. This genetic association study identi

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