rs115320831 - TMEM144 - AIDAP2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits - Unknown journal (n.d.) · Unknown authors · PubMed 27992416

  [INTRO] Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality, affect 25-30% of adults worldwide. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable, and gene identification should improve our understanding of sleep function, mechanisms linking sleep to disease, and development of novel therapies. We report single and multi-trait genome-wide association analyses (GWAS) of self-reported sleep duration, insomnia symptoms including difficulty initiating and/or maintaining sleep, and excessive daytime sleepiness in the UK Biobank (n=112,586), with discovery of loci for insomnia symptoms (near MEIS1, TMEM132E, CYCL1, TGFBI in females and WDR27 in mal

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