rs115306967 - TSBP1-AS1 - HLA-DRA

Magnitude 2.2 · 1 study on file

Reported associations

• A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer - Unknown journal (n.d.) · Unknown authors · PubMed 25217961

  ABSTRACT: Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three novel susceptibility loci were revealed at P<5×10-8; 15 variants were identified among men of European ancestry, 7 from multiethnic analyses and one was associated with early-onset prostate cancer. These 23 variants, in combination with the known prostate cancer risk variants, explain 33% of the familial risk of the disease in European ancestry populations. These findings

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