rs1152965 - MYRFL, PRANCR
Magnitude 2.2 · 1 study on file
Reported associations
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Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036
ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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joint-protective exercise program Moderate
Elevated knee osteoarthritis risk; targeted low-impact exercise maintains joint function and slows progression
150 min/week moderate-intensity low-impact exercise (swimming, cycling, walking, tai chi)
Lifestyle
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maintain healthy body weight Moderate
Obesity accelerates knee osteoarthritis progression; weight reduction decreases joint load and cartilage stress
Target BMI <25 kg/m2, or 5-10% weight loss if overweight
Screening
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baseline joint health assessment Moderate
Elevated osteoarthritis risk warrants baseline imaging to identify early changes and track progression
Baseline X-ray or ultrasound by age 40-45, repeat every 2-3 years if symptoms or risk factors present