rs1152733 - CASZ1 - HSPE1P24
Magnitude 4.5 · 1 study on file
Reported associations
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Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans - Unknown journal (n.d.) · Unknown authors · PubMed 38317187
ABSTRACT: Background African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. Methods Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed) rele
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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stroke risk assessment and prevention strategy Moderate
rs1152733-A allele is associated with 1.97-fold increased ischemic stroke risk; medical evaluation identifies additional risk factors and guides preventive interventions
Discuss personal and family stroke history with physician; request preventive screening assessment if indicated
Screening
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blood pressure Moderate
Hypertension is a major modifiable stroke risk factor; baseline and ongoing monitoring helps detect and manage elevated BP in someone with elevated genetic stroke risk
Monitor blood pressure regularly at home or clinic; maintain log to share with healthcare provider