Expressive

rs115270700 - C1QTNF12 - UBE2J2

Magnitude 4.5 · 1 study on file

Reported associations

  • Impact of Evolutionary Changes in Nonalcoholic Fatty Liver Disease on Lung Function Decline - Unknown journal (n.d.) · Unknown authors · PubMed 35611668

    ABSTRACT: Background/Aims A relationship between fatty liver and lung function impairment has been identified, and both are independently associated with metabolic dysfunction. However, the temporal relationship between changes in fatty liver status and lung function and their genome-wide association remain unclear. Methods This longitudinal cohort consisted of subjects who received serial health check-ups, including liver ultrasonography and spirometry, for ≥3 years between 2003 and 2015. Lung function decline rates were classified as "slow" and "accelerated" and compared among four different sonographic changes in steatosis status "normal," "improved," "worsened," and "persistent." A genome-wide association study was conducted between the two groups normal/impro

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • metabolic panel: fasting glucose, lipids, liver enzymes Moderate

    Insulin resistance and systemic inflammation mediate rs115270700 association with accelerated lung decline; monitoring guides intervention efficacy

    annually

Diet

  • weight management via caloric restriction Moderate

    Study shows rs115270700 C allele amplifies lung decline risk in metabolic dysfunction context; weight loss prevents fatty liver progression

    target 5-10% weight reduction if BMI >25

Discuss with your doctor

  • metabolic syndrome and fatty liver risk assessment Moderate

    rs115270700 shows pleiotropic effect linking metabolic dysfunction to both fatty liver and lung decline; clinical assessment identifies modifiable pathways

Lifestyle

  • regular physical activity Moderate

    rs115270700 C allele associated with accelerated FEV1 decline; physical activity improves insulin sensitivity and reduces systemic inflammation

    150 minutes moderate intensity weekly

Screening

  • spirometry for lung function decline Moderate

    rs115270700 C allele shows genome-wide significant association with accelerated FEV1 decline; baseline and serial screening enables early detection

    baseline spirometry, repeat annually or every 2 years