rs115269429 - ST3GAL1

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry∗ - Unknown journal (n.d.) · Unknown authors · PubMed 39163621

  ABSTRACT: Key Points The CYP2C and VKORC1 loci are the most important in determining warfarin dose requirements in individuals of African ancestry. We identified a biologically plausible locus (MALL) that could indirectly influence warfarin response through interactions with caveolin-1. Visual Abstract Abstract Warfarin dose requirements are highly variable because of clinical and genetic factors. Although genetic variants influencing warfarin dose have been identified in European and East Asian populations, more work is needed to identify African-specific genetic variants to help optimize warfarin dosing. We performed genome-wide association studies (GWASs) in 4 African cohorts from Uganda, South Africa, and Zimbabwe, totaling 989 warfarin-treated participants who reached stable dose and

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