rs11525841 - LINC00972 - SOCS5P1

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative - Unknown journal (n.d.) · Unknown authors · PubMed 26545240

  ABSTRACT: Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women's Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1-3) or moderate/severe POP (grades 2-3), while controls had grade 0 POP. We performed race-specific multiple logistic regression analyses between SNPs imputed to 1000 genomes in relation to POP (grade 0 vs 1-3; grade 0 vs 2-3) adjusting for age at diagnosis, body mass index, parity, and genetic ancestry. There were 1274 controls and 1427 cases of any POP and 317 cases of moderate/severe POP. Although none of the analyses reached genome-wide significance (p<5x1

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