rs115218101 - KRT18P1 - RN7SL471P
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers - Unknown journal (n.d.) · Unknown authors · PubMed 33667223
ABSTRACT: Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs121337
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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aerodigestive cancer risk from genetic variant Moderate
Genetic variant rs115218101 is associated with 1.21-fold increased risk of aerodigestive squamous cell cancer
Discuss genetic risk assessment and screening options with physician