Expressive

rs115169076 - ADAMTS12

Magnitude 2.2 · 1 study on file

Reported associations

  • BIOMARKER AND GENOMIC RISK FACTORS FOR LIVER FUNCTION TEST ABNORMALITY IN HAZARDOUS DRINKERS - Unknown journal (n.d.) · Unknown authors · PubMed 30589442

    ABSTRACT: Background: Alcohol dependence and long-term excessive alcohol use may cause liver damage, but only some patients develop cirrhosis. Similarly, high alcohol intake without evident liver disease often but not always produces abnormal enzymatic liver function tests, particularly gamma-glutamyl transferase (GGT). We postulate that the factors predisposing to cirrhosis in alcoholics and to liver enzyme abnormality in drinkers are similar, and that biochemical liver function tests could therefore be useful as markers of risk of alcoholic liver disease in excessive drinkers. Methods: Data from participants in twin and twin-family studies on alcohol use and dependence were used to identify 1003 people who had reported excessive alcohol intake (28 drinks or more per week). 962 of these p

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • excessive alcohol consumption Moderate

    ADAMTS12 rs115169076 is associated with increased aspartate aminotransferase elevation in response to alcohol, suggesting heightened susceptibility to alcohol-related liver injury.

Discuss with your doctor

  • alcohol sensitivity and individual liver enzyme response Moderate

    rs115169076 influences aspartate aminotransferase elevation in response to alcohol, indicating a genetic component to individual alcohol metabolism and liver vulnerability.

Screening

  • aspartate aminotransferase level baseline and periodic assessment Moderate

    rs115169076 carriers show elevated AST in response to alcohol, requiring baseline and periodic liver function testing to establish individual response pattern.

    baseline AST screening, then annually if alcohol consumption present