rs115071607 - GRIK2 - R3HDM2P2
Magnitude 2.2 · 1 study on file
Reported associations
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Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program - Unknown journal (n.d.) · Unknown authors · PubMed 38162683
ABSTRACT: Introduction: Apparent treatment-resistant hypertension (aTRH) is characterized by the use of four or more antihypertensive (AHT) classes to achieve blood pressure (BP) control. In the current study, we conducted single-variant and gene-based analyses of aTRH among individuals from 12 Trans-Omics for Precision Medicine cohorts with whole-genome sequencing data. Methods: Cases were defined as individuals treated for hypertension (HTN) taking three different AHT classes, with average systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg, or four or more medications regardless of BP (n = 1,705). A normotensive control group was defined as individuals with BP < 140/90 mmHg (n = 22,079), not on AHT medication. A second control group comprised individuals who were treatment responsive on o
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss hypertension treatment resistance Moderate
GRIK2 risk allele is genetically associated with poorer response to standard antihypertensive medications
Share this genetic result with your doctor when discussing blood pressure management
Screening
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Blood pressure monitoring Moderate
GRIK2 risk allele A is associated with treatment-resistant hypertension in GWAS of 23784 subjects
If hypertensive, check blood pressure regularly; consider home monitoring if standard medications are ineffective