rs115034159 - GNG8
Magnitude 2.2 · 2 studies on file
Reported associations
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Identifying missing pieces in color vision defects: a genome-wide association study in Silk Road populations - Unknown journal (n.d.) · Unknown authors · PubMed 37359372
ABSTRACT: Introduction: Color vision defects (CVDs) are conditions characterized by the alteration of normal trichromatic vision. CVDs can arise as the result of alterations in three genes (OPN1LW, OPN1MW, OPN1SW) or as a combination of genetic predisposition and environmental factors. To date, apart from Mendelian CVDs forms, nothing is known about multifactorial CVDs forms. Materials and Methods: Five hundred and twenty individuals from Silk Road isolated communities were genotyped and phenotypically characterized for CVDs using the Farnsworth D-15 color test. The CVDs traits Deutan-Protan (DP) and Tritan (TR) were analysed. Genome Wide Association Study for both traits was performed, and results were corrected with a False Discovery Rate linkage-based approach (FDR-p). Gene expression o
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Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 35320353
ABSTRACT: Interindividual differences in generation of new fat cells determine body fat and type 2 diabetes risk. In the GENetics of Adipocyte Lipolysis (GENiAL) cohort, which consists of participants who have undergone abdominal adipose biopsy, we performed a genome-wide association study (GWAS) of fat cell number (n = 896). Candidate genes from the genetic study were knocked down by siRNA in human adipose-derived stem cells. We report 318 single nucleotide polymorphisms (SNPs) and 17 genetic loci displaying suggestive (P < 1 × 10−5) association with fat cell number. Two loci pass threshold for GWAS significance, on chromosomes 2 (lead SNP rs149660479-G) and 7 (rs147389390-deletion). We filtered for fat cell number-associated SNPs (P < 1.00 × 10−5) using evidence of genotype-speci
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular aerobic exercise for metabolic health Moderate
rs115034159-T associated with increased abdominal adipocyte number, indicating metabolic risk
Aim for 150 minutes per week of moderate-intensity aerobic activity
Screening
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Tritan color vision defect screening Moderate
rs115034159-T allele associated with blue-yellow color vision deficiency (Tritan)
Consider formal color vision testing and discussion with eye care provider