rs115009136 - RN7SL201P - LYARP1
Magnitude 4.5 · 1 study on file
Reported associations
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Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 34734193
ABSTRACT: Summary Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Maintain strong social connections Moderate
This variant shows significant interaction with social support on systolic blood pressure; low social support may exert a larger effect in carriers
Regularly engage with family, friends, community; prioritize relationship quality
Screening
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Regular blood pressure monitoring Moderate
Gene-environment interaction suggests this variant's effect on BP is modified by social support; monitoring helps detect contextual changes
Annual baseline, more frequent if experiencing social isolation or elevated BP