rs114969316 - ACTBP8 - RNGTT

Magnitude 2.0 · 1 study on file

Reported associations

• GWAS and Systems Biology Analysis of Depressive Symptoms among Smokers from the COPDGene Cohort - Journal of affective disorders (2019) · Heinzman JT, Hoth KF, Cho MH, Sakornsakolpat P, Regan EA, Make BJ, Kinney GL, Wamboldt FS, Holm KE, Bormann N, Robles J, Kim V, Iyer AS, Silverman EK, Crapo JD, Han S, Potash JB, Shinozaki G · PubMed 30219690

  ABSTRACT: Background: Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. Methods: Data were from 9,716 COPDGene subjects with ≥ 10 pack-year history. Depression was defined as antidepressant use and/or a HADS depression subscale score ≥ 8. Non-Hispanic White (6,576) and African-American (3,140) subsets were analyzed. A GWAS pipeline identified SNPs associated with depression in each group. Network analysis software analyzed gene interactions through common biological pathways, genetic interactions, and tissue-specific gene expression. Results: The mean age was 59.4 years (SD 9.0) with 46.5% female subjects. Depression was in

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