Expressive

rs114948768 - HECTD4

Magnitude 2.2 · 1 study on file

Reported associations

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • sodium restriction for blood pressure control Moderate

    Sodium intake directly affects vascular function and blood pressure regulation; reduction is standard management for genetic BP predisposition

    Target under 2300 mg sodium daily

Exercise

  • aerobic exercise for blood pressure management Moderate

    Regular aerobic exercise enhances vascular compliance and endothelial function, reducing blood pressure; especially important given genetic predisposition

    150 minutes moderate-intensity aerobic exercise weekly

Screening

  • diastolic blood pressure screening Moderate

    HECTD4 variant increases diastolic blood pressure via altered vascular function and regulation; carriers show dose-dependent elevation of 0.262 mmHg per risk allele

    Annual blood pressure assessment; increase frequency if baseline elevated