rs114888479 - LINC02199
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans - Unknown journal (n.d.) · Unknown authors · PubMed 35165267
ABSTRACT: Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead S
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cardiovascular risk assessment based on genetic findings Moderate
Carriers of rs114888479 G allele have increased carotid intima-media thickness risk, warranting physician review for comprehensive cardiovascular risk evaluation.
Exercise
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Regular aerobic cardiovascular exercise Moderate
Genetic predisposition to increased arterial thickness warrants engagement in exercises that improve arterial compliance.
150 minutes moderate-intensity aerobic exercise per week
Screening
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Carotid intima-media thickness screening Moderate
Variant rs114888479 G allele associates with increased carotid intima-media thickness, a marker of accelerated atherosclerosis.
Carotid ultrasound imaging to assess intima-media thickness