rs114864815 - LINC01149 - HCP5

Magnitude 2.8 · 1 study on file

Reported associations

• Genetic variation in the HLA region is associated with susceptibility to herpes zoster - Unknown journal (n.d.) · Unknown authors · PubMed 25297839

  ABSTRACT: Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as shingles. Although reactivation may be related to immune suppression, aging and female sex, most inter-individual variability in re-emergence risk has not been explained to date. We performed a genome-wide association analyses in 22 981 participants (2280 shingles cases) from the electronic Medical Records and Genomics Network. Using Cox survival and logistic regression, we identified a genomic region in the combined and European ancestry groups that has an age of onset effect reaching genome-wide significance (P>1.0 × 10−8)

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