rs11477757 - GNAS
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of type 2 diabetes loci in 433,540 East Asian individuals - Unknown journal (n.d.) · Unknown authors · PubMed 32499647
ABSTRACT: SUMMARY Meta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci newly implicated in T2D predisposition. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. New associations include signals in/near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Type 2 diabetes screening Moderate
GNAS rs11477757 risk allele increases Type 2 diabetes susceptibility through altered G-protein signaling
Annual fasting glucose and HbA1c testing starting at age 40, or earlier if additional risk factors present
- GWAS_CATALOG:32499647