rs114770276 - THADA
Magnitude 2.8 · 1 study on file
Reported associations
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A cross-disorder study to identify causal relationships, shared genetic variants, and genes across 21 digestive disorders - Unknown journal (n.d.) · Unknown authors · PubMed 37965154
ABSTRACT: Summary Digestive disorders are a significant contributor to the global burden of disease and seriously affect human quality of life. Research has already confirmed the presence of pleiotropic genetic loci among digestive disorders, and studies have explored shared genetic factors among pan-cancers, including various malignant digestive disorders. However, most cross-phenotype studies within the digestive tract system have been limited to a few traits, with no systematic coverage of common benign and malignant digestive disorders. Here, we analyzed data from the UK Biobank to investigate 21 digestive disorders, exploring the genetic correlations and causal relationships between diseases, as well as the common genetic factors and potential biological pathways driving these relatio
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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dietary fiber Moderate
Increased fiber intake reduces cholesterol absorption and increases bile acid excretion, reducing gallstone formation
Aim for 25-30 grams of fiber daily from whole grains, vegetables, and fruits
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high saturated fat intake Moderate
Saturated fat increases cholesterol saturation in bile, promoting gallstone formation
Limit saturated fat to less than 10% of daily calories
Lifestyle
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body weight stability Moderate
Both obesity and rapid weight loss increase gallstone formation risk; genetic predisposition compounds this effect
Maintain stable weight and avoid rapid weight cycling or fasting
Screening
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gallstone screening with ultrasound Moderate
Genetic variant shows strong association with cholelithiasis development, potentially warranting periodic assessment
Discuss with healthcare provider about screening intervals and symptom monitoring