Expressive

rs11471653

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

  • A genetic map of human metabolism across the allele frequency spectrum - Unknown journal (n.d.) · Unknown authors · PubMed 41044249

    ABSTRACT: Genetic studies of human metabolism have been limited in scale and allelic breadth. Here we provide a data-driven map of the genetic regulation of circulating small molecules and lipoprotein characteristics (249 traits) measured using proton nuclear magnetic resonance spectroscopy across the allele frequency spectrum in ~450,000 individuals. Trans-ancestral meta-analyses identify 29,824 locus-metabolite associations mapping to 753 regions with effects largely consistent between men and women and large ancestral groups represented in UK Biobank. We observe and classify extreme genetic pleiotropy, identify regulators of lipid metabolism, and assign effector genes at >100 loci through rare-to-common allelic series. We propose roles for genes less established in metabolic control (

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and added sugars Moderate

    These increase triglyceride levels; SNP indicates genetic predisposition to elevated triglycerides, making dietary modification especially important

    Limit to less than 10 percent of daily calories

Discuss with your doctor

  • triglyceride management given genetic predisposition Moderate

    SNP predisposes to elevated triglycerides and altered VLDL composition; professional guidance optimizes preventive strategies based on actual lipid values

Exercise

  • regular cardiovascular exercise Moderate

    Exercise reduces triglycerides and increases HDL; especially beneficial given genetic predisposition to elevated triglycerides

    Aim for at least 150 minutes of moderate-intensity aerobic activity per week

Screening

  • lipid panel screening Moderate

    SNP associated with triglyceride and HDL levels; genetic predisposition warrants regular monitoring to detect abnormalities early

    Check lipid panel (fasting) every 1-2 years or per clinical guidelines