rs1147107 - RASSF3
Magnitude 4.5 · 1 study on file
Reported associations
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk - Unknown journal (n.d.) · Unknown authors · PubMed 36914875
ABSTRACT: Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of interve
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular aerobic exercise Moderate
Aerobic activity helps maintain lung function, particularly important given genetic predisposition to lower baseline values
aim for 150 minutes per week of moderate-intensity aerobic activity
Lifestyle
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smoking and air pollution exposure Moderate
Genetic predisposition to lower lung function increases respiratory damage from smoking and pollutants
avoid smoking completely, minimize indoor and outdoor air pollution exposure
Screening
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baseline FEV1/FVC spirometry testing Moderate
rs1147107 A allele is associated with reduced FEV1/FVC ratio in genome-wide association study
obtain baseline spirometry if not done recently, then annual monitoring