rs114692817 - SPMAP2L
Magnitude 4.5 · 1 study on file
Reported associations
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Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. - Nature communications (2020) · Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS · PubMed 32887889
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in two large, population-based cohorts: the UK Biobank (408,786 European ancestry individuals; 48,961 cancer cases) and the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging cohorts (66,526 European ancestry individuals; 16,001 cancer cases). The GWAS detect 21 genome-wide significant associations independent of previously reported results. Investigations of pleiotropy identify 12 cancer pairs exhibiting either positive or negative genetic correlations; 25 pleiot
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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thyroid cancer genetic risk Moderate
GWAS finding shows 2.4-fold increased risk for rs114692817 T allele carriers
Schedule discussion about risk assessment, appropriate screening, and symptom awareness
- GWAS_CATALOG:32887889
Screening
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thyroid cancer screening Moderate
Genetic variant rs114692817 shows strong association with 2.4-fold increased thyroid cancer risk
Discuss thyroid screening protocol with healthcare provider, consider baseline evaluation if not previously done
- GWAS_CATALOG:32887889