rs114686607 - CFAP107

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide associations of human gut microbiome variation and implications for causal inference analyses - Unknown journal (n.d.) · Unknown authors · PubMed 32572223

  ABSTRACT: Recent population-based and clinical studies have identified a range of factors associated with human gut microbiome variation. Murine quantitative trait loci, human twin studies and microbiome genome-wide association studies (mGWAS) have provided evidence for genetic contributions to microbiome composition. Despite this, there is still poor overlap in genetic association across human studies. Using appropriate taxon-specific models along with support from independent cohorts, we show association between human host genotype and gut microbiome variation. We also suggest that interpretation of applied analyses using genetic associations is complicated by the likely overlap between genetic contributions and heritable components of host environment. Using fecal derived 16S rRNA gene

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