Expressive

rs11465820 - IL23R

Magnitude 4.5 · 1 study on file

Reported associations

  • GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis - Unknown journal (n.d.) · Unknown authors · PubMed 40075078

    ABSTRACT: Sarcoidosis is a complex inflammatory disease with a strong genetic component. Here, we perform a genome-wide association study in 9755 sarcoidosis cases to identify risk loci and map associated genes. We then use transcriptome-wide association studies and enrichment analyses to explore pathways involved in sarcoidosis and use Mendelian randomization to examine associations with modifiable factors and circulating biomarkers. We identify 28 genomic loci associated with sarcoidosis, with the C1orf141-IL23R locus showing the largest effect size. We observe gene expression patterns related to sarcoidosis in the spleen, whole blood, and lung, and highlight 75 tissue-specific genes through transcriptome-wide association studies. Furthermore, we use enrichment analysis to establish key

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular moderate-to-vigorous physical activity Low

    MVPA associated with 34% reduced sarcoidosis risk; exercise reduces IL-23 signaling and inflammatory cytokine production

    Aim for 150 minutes weekly; consult physician before starting new programs

Lifestyle

  • Maintain healthy body mass index Moderate

    BMI causally associated with sarcoidosis risk (OR 1.26 per SD increase); excess weight amplifies inflammatory burden

    Target BMI 18.5-24.9; consult nutritionist if overweight

Screening

  • Sarcoidosis symptoms and respiratory evaluation Moderate

    rs11465820 A allele increases sarcoidosis risk 2.08-fold via IL23R inflammatory pathway; early detection improves outcomes

    Report respiratory symptoms, fatigue, or joint pain to physician; consider baseline pulmonary evaluation