rs11465729 - IL18RAP

Magnitude 2.8 · 1 study on file

Reported associations

• The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases - Unknown journal (n.d.) · Unknown authors · PubMed 28915241

  ABSTRACT: Associations between epigenetic alterations and disease status have been identified for many diseases. However, there is no strong evidence that epigenetic alterations are directly causal for disease pathogenesis. In this study, we combined SNP and DNA methylation data with measurements of protein biomarkers for cancer, inflammation or cardiovascular disease, to investigate the relative contribution of genetic and epigenetic variation on biomarker levels. A total of 121 protein biomarkers were measured and analyzed in relation to DNA methylation at 470,000 genomic positions and to over 10 million SNPs. We performed epigenome-wide association study (EWAS) and genome-wide association study (GWAS) analyses, and integrated biomarker, DNA methylation and SNP data using between 698 and

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