rs11465670 - SDR42E1P5 - IL18RAP

Magnitude 2.0 · 1 study on file

Reported associations

• Genome Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys - The Journal of pediatrics (2017) · Wattacheril J, Lavine JE, Chalasani NP, Guo X, Kwon S, Schwimmer J, Molleston JP, Loomba R, Brunt EM, Chen YI, Goodarzi MO, Taylor KD, Yates KP, Tonascia J, Rotter JI · PubMed 28918882

  ABSTRACT: Objective To identify genetic loci associated with features of nonalcoholic fatty liver disease. (NAFLD) histologic severity in a cohort of Hispanic boys. Study design 234 eligible Hispanic boys age 2-17 years with clinical, laboratory and histological data enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) were included in the analysis of 624,297 single nucleotide polymorphisms (SNPs). After elimination of 4 outliers and 22 boys with cryptic relatedness, association analyses were performed on 208 DNA samples with corresponding liver histology. Logistic regression analyses were carried out for qualitative traits and linear regression analyses were applied for quantitative traits. Results The median age and body mass index Z-score were 12.0 y (inte

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