rs11465543 - IL17F

Magnitude 2.0 · 1 study on file

Reported associations

• Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity - Alcoholism, clinical and experimental research (2019) · Edwards AC, Deak JD, Gizer IR, Lai D, Chatzinakos C, Wilhelmsen KP, Lindsay J, Heron J, Hickman M, Webb BT, Bacanu SA, Foroud TM, Kendler KS, Dick DM, Schuckit MA · PubMed 30276832

  ABSTRACT: Background: Previous studies indicate that low initial sensitivity to alcohol may be a risk factor for later alcohol misuse. Evidence suggests that initial sensitivity is influenced by genetic factors, but few molecular genetic studies have been reported. Methods: We conducted a meta-analysis of two population-based genome-wide association studies of the Self-Rating of the Effects of Alcohol scale. Our final sample consisted of 7339 individuals (82.3% of European descent; 59.2% female) who reported having used alcohol at least 5 times. In addition, we estimated SNP-based heritability and conducted a series of secondary aggregate genetic analyses. Results: No individual locus reached genome-wide significance. Gene- and set-based analyses, both overall and using tissue-specific exp

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