rs1146473 - F3 - SLC44A3-AS1
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation - Unknown journal (n.d.) · Unknown authors · PubMed 37248441
ABSTRACT: Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite a
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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DASH diet or sodium restriction High
Blood pressure causally increases SCAD risk; dietary sodium reduction and DASH diet lower blood pressure in high-risk carriers
Follow DASH diet or reduce sodium intake to <2300 mg/day
Exercise
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aerobic exercise for blood pressure control High
Blood pressure is a causal risk factor for SCAD; aerobic exercise effectively lowers blood pressure and reduces SCAD risk
150 minutes per week moderate-intensity aerobic exercise
Screening
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blood pressure High
Mendelian randomization demonstrates blood pressure causally increases SCAD risk; rs1146473 carriers have elevated genetic SCAD risk
Check blood pressure regularly; target systolic <120 mmHg