Expressive

rs11464691 - CCR7 - SMARCE1

Magnitude 2.2 · 1 study on file

Reported associations

  • Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology - Unknown journal (n.d.) · Unknown authors · PubMed 29083406

    ABSTRACT: Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS, n=360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P<3x10-8), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology. Disease-specific effects were detected for only six variants, confirming that most represent shared risk factors. Tissue-specific heritability and biological process enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity. Six target

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to allergic disease Moderate

    Carrier of variant associated with significantly increased allergic disease risk for informed management planning.

Lifestyle

  • Minimize indoor allergen exposure Moderate

    Genetic predisposition to allergic disease suggests heightened susceptibility to environmental triggers.

    Vacuum weekly, maintain humidity 30-50%, wash bedding twice weekly in hot water, minimize pet dander indoors.

Screening

  • Annual asthma assessment Moderate

    Genetic predisposition to asthma confirmed by large genome-wide association study.

    Screen annually for asthma symptoms: persistent cough, shortness of breath, chest tightness, wheezing.

  • Comprehensive allergy testing Moderate

    Variant significantly associated with allergic disease risk (asthma, hay fever, eczema) in genome-wide association of 360,838 individuals.