Expressive

rs114643265 - DNER

Magnitude 4.5 · 1 study on file

Reported associations

  • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk - Unknown journal (n.d.) · Unknown authors · PubMed 36914875

    ABSTRACT: Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of interve

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic exercise for respiratory fitness Moderate

    Aerobic training increases FEV1/FVC ratio and improves cardiovascular-respiratory capacity; helps optimize lung function given genetic predisposition

    150 minutes moderate-intensity aerobic exercise per week

Lifestyle

  • Tobacco smoke and environmental respiratory irritants Moderate

    DNER variants associated with reduced lung function; environmental irritants cause additional damage beyond genetic risk

Screening

  • Spirometry to assess baseline lung function Moderate

    DNER variants affect FEV1/FVC ratio; spirometry measures this ratio to establish baseline and guide clinical decision-making

    Obtain baseline spirometry; repeat per physician recommendation based on results