Expressive

rs114623663 - CLNK

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce high-purine foods if serum urate is elevated Moderate

    Purines from dietary sources are metabolized to uric acid; reduction may help manage elevated urate in genetically predisposed individuals

    If serum urate >6.8 mg/dL, limit red meat, organ meats, shellfish, and high-fructose beverages

Discuss with your doctor

  • urate-lowering therapy if lifestyle changes are insufficient Moderate

    Genetic predisposition to elevated urate may warrant pharmacologic management to prevent gout and complications

    If serum urate remains >6.8 mg/dL after 3 months of dietary modification, discuss urate-lowering medications

Screening

  • serum urate concentration High

    rs114623663 T allele is associated with higher serum urate levels, a risk factor for gout and hyperuricemia

    Check fasting serum urate at baseline and annually; manage if result exceeds 6.8 mg/dL