rs11455295 - RNU6-8 - KIAA1143P1
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents - Unknown journal (n.d.) · Unknown authors · PubMed 36718908
ABSTRACT: Background Genetics, along with lifestyle and behavioral characteristics, play an important role in hypertension in adults. Our aim was to identify genetic variants associated with blood pressure in childhood and adolescence. Methods and Results We conducted a candidate single‐nucleotide polymorphism (SNP) analysis and genome‐wide association study among 9778 participants aged <18 years in BioVU, the Vanderbilt University Medical Center biobank. The outcome was childhood blood pressure percentile from age 0 to 18 years. For the candidate SNP analysis, a total of 457 previously identified SNPs were examined. Linear regression was used to test the association between genetic variants and median systolic blood pressure (SBP) percentile. Adjusted models included median age, s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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childhood blood pressure and cardiovascular risk Moderate
Carriers of rs11455295-A have genome-wide significantly higher childhood systolic BP percentiles, indicating elevated cardiovascular risk trajectory
Baseline BP by age 8; annual monitoring with cardiovascular health counseling