rs114544105 - HLA-DQB1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets - Unknown journal (n.d.) · Unknown authors · PubMed 28166213

  ABSTRACT: Chronic Obstructive Pulmonary Disease (COPD) is characterised by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratios per standard deviation of the risk score (~6 alleles) (95% confidence interval) 1.24 (1.20-1.27), P=5.05x10-49) and we observed a 3.7 fold difference in COPD risk between highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in development, elastic fibres and epigenetic regulation pathwa

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