rs114538007 - SBF2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 40708016
ABSTRACT: Background Alzheimer's disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. However, sample sizes in African ancestry (AA) cohorts have been underpowered to perform stratified analyses. Methods We generated genome-wide association study datasets stratified by sex, age at onset (< 75 vs ≥ 75), and APOE-ε4 carrier status in AA cohorts from MVP and the Alzheimer's Disease Genetics Consortium (ADGC). Outcomes in MVP were AD and related dementias (ADRD; n = 4073 cases and 19,648 controls) and proxy dementia (i.e., reported dementia in a parent, n = 6216 cases and 21,566 controls) while ADGC
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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early cognitive screening for Alzheimer's disease risk Moderate
The A allele at rs114538007 is associated with early-onset Alzheimer's disease risk.
Discuss with healthcare provider about cognitive baseline assessment starting in 4th-5th decade