rs11453507 - NEBL

Magnitude 2.2 · 1 study on file

Reported associations

• Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program - Unknown journal (n.d.) · Unknown authors · PubMed 34446064

  ABSTRACT: Background Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturat

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