rs1145191 - LINC02702 - BUD13
Magnitude 2.2 · 1 study on file
Reported associations
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A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907
ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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fasting glucose and lipid panel Moderate
Genetic predisposition to metabolic syndrome warrants monitoring of glucose and lipid metabolism across tissues including liver and skeletal muscle
annual or biennial fasting glucose, triglycerides, HDL cholesterol testing
Screening
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metabolic syndrome component screening Moderate
rs1145191 C allele is strongly associated with metabolic syndrome risk (p=1.00e-12, effect=0.075 per allele, n=107230)
annual assessment of waist circumference, blood pressure, fasting glucose, triglycerides, HDL cholesterol