rs1145089 - RNU6-953P - GATM
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci - Unknown journal (n.d.) · Unknown authors · PubMed 35347128
ABSTRACT: Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple bottlenecks and expansions that have shaped its history, and the enrichment for many otherwise rare alleles that has resulted. Here, we report genetic associations for 1391 plasma metabolites in 6136 men from the late-settlement region of Finland. We identify 303 novel association signals, more than one third at variants rare or enriched in Finns. Many of these signals identify genes not previously implicated in metabolite genome-wide association studies and suggest mechanisms for diseases and disease-related traits. The Finnis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Maintain adequate hydration Low
Proper hydration supports kidney function when managing elevated creatine metabolism from this variant
Drink 8-10 glasses of water daily, more if exercising
Screening
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Kidney function Moderate
Elevated creatine from this variant increases kidney metabolic load; monitoring helps detect early dysfunction
Check serum creatinine and eGFR annually
Supplements
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Creatine monohydrate supplements Moderate
This variant increases endogenous creatine; supplementation would redundantly elevate kidney metabolic burden