rs1144708 - MSH5, MSH5-SAPCD1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants - Unknown journal (n.d.) · Unknown authors · PubMed 37085903

  ABSTRACT: Background Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability and being partly determined by a genetic component, the genetic underpinnings explaining the high rates of comorbidity remain largely unclear and there are no conclusive data on the temporal relationship between them. Exploring the overlapping genetic architecture between IBS and mental conditions may help to identify novel genetic loci and biological mechanisms underlying IBS and causal relationships between them. Methods We quantified the genetic overlap between IBS, neuroticism, depression and anxiety, conducted a multi-trait genome-wide association study (GWAS) consideri

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