Expressive

rs114407963 - CYP20A1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

  • Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878

    ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Heart-healthy diet for lipid management Moderate

    Variant associated with elevated LDL cholesterol; dietary modifications address modifiable cardiovascular risk

    Emphasize whole grains, vegetables, lean proteins; limit saturated fat and processed foods

Discuss with your doctor

  • Cardiovascular risk assessment and prevention strategy Moderate

    Genetic variant associated with multiple cardiovascular risk factors; clinical assessment guides preventive approaches

Exercise

  • Regular aerobic exercise for blood pressure management Moderate

    Variant associated with elevated pulse pressure and diastolic blood pressure; aerobic exercise reduces blood pressure

    150 minutes moderate intensity aerobic exercise weekly or 75 minutes vigorous intensity

Screening

  • Blood pressure and lipid panel screening Moderate

    Variant associated with higher pulse pressure, diastolic blood pressure, and LDL cholesterol in large population cohorts

    Annual blood pressure check and lipid panel; more frequent if any values elevated