Expressive

rs1143756 - SCYL1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores - Unknown journal (n.d.) · Unknown authors · PubMed 34989438

    ABSTRACT: Abstract Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and horizontal pleiotropy analysis of S/DBP summary statistics from the UK Biobank (UKB)‐International Consortium for Blood Pressure (ICBP) (UKB‐ICBP) BP genome‐wide association study and construct a composite genetic risk score (GRS) by including pleiotropic variants. The composite GRS captures greater (1.11-3.26 fold) heritability for BP traits and increases (1.09‐ and 2.01‐fold) Nagelkerke's R 2 for hypertension and CVD. We replicated 118 novel BP horizontal pleiotropic variants including 18 novel BP loci using summary statistics from the Million Veteran Program (MVP) study

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Sodium intake Moderate

    Dietary sodium influences blood pressure; genetic predisposition to higher blood pressure makes sodium restriction more important.

    Target less than 2300 mg sodium daily

Discuss with your doctor

  • Hypertension screening and prevention Moderate

    rs1143756 associates with elevated blood pressure; medical guidance on prevention is warranted.

Lifestyle

  • Aerobic exercise for blood pressure management Moderate

    Aerobic exercise reduces blood pressure; rs1143756 genotype predisposes to higher blood pressure values.

    150 minutes moderate-intensity aerobic activity per week

Screening

  • Blood pressure monitoring Moderate

    rs1143756 associates with higher systolic and diastolic blood pressure; genetic predisposition warrants regular monitoring.

    Check blood pressure at least twice yearly