rs114368656 - SYN3

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci - Unknown journal (n.d.) · Unknown authors · PubMed 29860282

  ABSTRACT: Genome-Wide Association Studies of imaging-derived biomarkers in Alzheimer's disease have focused on phenotypes derived from single imaging modalities. Scelsi et al. report the first use of a multimodal phenotype, derived through disease progression modelling, and identify a novel variant that is protective against conversion from healthy ageing to Alzheimer's disease. Abstract Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the potential to provide important insights into pathogenesis. Moving away from simple case-control definitions, there is considerable interest in using quantitative endophenotypes, such as those derived from imaging as outcome measures. Previous genome-wide association studies of imaging-derived biomarkers in

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