Expressive

rs114366450 - ASIC2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans - Unknown journal (n.d.) · Unknown authors · PubMed 35165267

    ABSTRACT: Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead S

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean-style dietary pattern Moderate

    Mediterranean diet reduces carotid intima-media thickness and cardiovascular event risk

    Emphasize vegetables, fruits, whole grains, fish, olive oil; limit processed foods and salt

Exercise

  • Aerobic exercise for cardiovascular health Moderate

    Exercise improves vascular endothelial function and reduces carotid intima-media thickness progression

    150 minutes moderate-intensity aerobic activity weekly, such as brisk walking or cycling

Screening

  • Blood pressure monitoring and control Moderate

    Hypertension accelerates carotid intima-media thickness progression; controlling BP reduces risk

    Home or clinic BP checks quarterly; target less than 130/80 mm Hg

  • Carotid ultrasound screening Moderate

    Assess baseline carotid intima-media thickness given genetic association with increased cIMT

    Consider baseline ultrasound by age 40-50; frequency of repeat screening per physician

  • Lipid profile monitoring Moderate

    Dyslipidemia worsens carotid intima-media thickness progression; lipid control reduces vascular risk

    Annual lipid panel; target LDL less than 100 mg/dL; discuss statin use with physician if indicated