rs114363831 - YWHAQ
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk - Unknown journal (n.d.) · Unknown authors · PubMed 37108169
ABSTRACT: Infectious diseases still threaten global human health, and host genetic factors have been indicated as determining risk factors for observed variations in disease susceptibility, severity, and outcome. We performed a genome-wide meta-analysis on 4624 subjects from the 10,001 Dalmatians cohort, with 14 infection-related traits. Despite a rather small number of cases in some instances, we detected 29 infection-related genetic associations, mostly belonging to rare variants. Notably, the list included the genes CD28, INPP5D, ITPKB, MACROD2, and RSF1, all of which have known roles in the immune response. Expanding our knowledge on rare variants could contribute to the development of genetic panels that could assist in predicting an individual's life-long susceptibility to major in
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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influenza prevention and prophylaxis options Moderate
Genetic finding indicates above-average influenza risk; discussion optimizes prevention strategy for individual circumstances.
share rs114363831 YWHAQ genetic finding; discuss vaccination timing, antivirals, and exposure prevention
Screening
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annual influenza vaccination Moderate
YWHAQ rs114363831 risk allele carriers show 1.83-fold increased influenza infection frequency; vaccination addresses identified genetic susceptibility.
confirm receipt of annual influenza vaccine; consider early vaccination in seasonal cycle