Expressive

rs114357009 - HCG15, ZNF311

Magnitude 2.2 · 1 study on file

Reported associations

  • Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. - The European respiratory journal (2020) · Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA, Liang L · PubMed 31619474

    Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and the causal link between asthma and mental health disorders.We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from the UK Biobank and eight mental health disorders from the Psychiatric Genomics Consortium: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder, eating disorder, major depressive disorder (MDD), post-traumatic stress disorder and schizophrenia (sample size 9537-394 283).In the single-trait genome-wide association analysis,

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Preventive asthma management and medication options Moderate

    Genetic risk warrants proactive medical strategy including assessment for controller therapy and personalized prevention.

Exercise

  • Regular aerobic exercise program Moderate

    Aerobic conditioning improves respiratory function and may modulate immune pathways related to asthma pathogenesis.

    150 minutes per week of moderate-intensity aerobic activity (brisk walking, cycling, swimming).

Lifestyle

  • Exposure to air pollution and respiratory allergens Moderate

    Genetic predisposition increases susceptibility to environmental triggers; exposure reduction lowers exacerbation risk.

    Use HEPA air filters; monitor local air quality; plan outdoor activities during low-pollution periods.

Screening

  • Asthma screening and pulmonary function testing Moderate

    Strong genetic association with asthma indicates heightened respiratory disease susceptibility requiring baseline assessment.

    Arrange baseline spirometry; discuss with physician at next appointment.