rs114334738 - LINGO2
Magnitude 2.8 · 1 study on file
Reported associations
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Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations - Unknown journal (n.d.) · Unknown authors · PubMed 28498854
ABSTRACT: Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.25×10−8) for either systolic and diastolic blood pressure, hyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Dietary sodium reduction Moderate
Sodium restriction lowers blood pressure; variant associated with higher diastolic BP
Maintain sodium intake below 2300 mg per day
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Regular aerobic exercise Moderate
Aerobic activity reduces blood pressure; LINGO2 variant predisposes to elevated diastolic BP
150 minutes moderate-intensity aerobic exercise per week
Screening
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Blood pressure monitoring Moderate
LINGO2 variant associated with increased diastolic blood pressure in large cohort
Annual or biannual blood pressure checks starting in early adulthood