Expressive

rs114298671 - MSANTD1 - RGS12

Magnitude 2.0 · 2 studies on file

Reported associations

  • Exploring the genetic architecture of multiple long-term conditions using a genome-wide association study in the UK Biobank population - Scientific reports (2025) · Nair ATN, Witham M, Sayer AA, Cordell HJ, Pearson ER · PubMed 41353206

    ABSTRACT: The prevalence of multiple long-term conditions (MLTC) is increasing. It is essential to develop strategies to prevent and manage MLTC; however, the biological mechanisms underlying MLTC are not yet clearly understood. We used UK Biobank data as part of the ADMISSION research collaborative to identify genetic drivers for MLTC. We used the UK Biobank (UKBB) self-reported illness data to characterise MLTC (defined as two or more long-term conditions) using 51 common disease labels. A genome-wide association study (GWAS) was conducted for MLTC and complex MLTC (complex MLTC was defined as having three or more diseases from the 51 self-reported diseases, with these three diseases additionally belonging to different body systems), and post-GWAS analyses were conducted to explore the g

  • Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging - Nature aging (2023) · Rosoff DB, Mavromatis LA, Bell AS, Wagner J, Jung J, Marioni RE, Davey Smith G, Horvath S, Lohoff FW · PubMed 37550455

    ABSTRACT: The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological underpinnings; however, aging-related endpoints have been primarily assessed individually. Using data from these traits and multivariate genome-wide association study methods, we modeled their underlying genetic factor ('mvAge'). mvAge (effective n = ~1.9 million participants of European ancestry) identified 52 independent variants in 38 genomic loci. Twenty variants were novel (not reported in input genome-wide association studies). Transcriptomic imputation identified age-relevant genes, including VEGFA and PHB1. Drug-target Mendelian randomization with metformin target genes showed a beneficial im

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