Expressive

rs114291795 - MICA

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population. - The lancet. Diabetes & endocrinology (2018) · Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, Carvajal A, Lucena MI, Ponce ES, Molokhia M, Martin J, Axelsson T, Yue QY, Magnusson PK, Wadelius M · PubMed 27157822

    Drug-induced agranulocytosis is a potentially life-threatening adverse reaction. Genome-wide association studies (GWASs) in ethnic Chinese people in Taiwan and Hong Kong have shown an association between agranulocytosis induced by antithyroid drugs and the HLA alleles HLA-B38:02 and HLA-DRB108:03. We aimed to identify genetic variants associated with antithyroid drug-induced agranulocytosis in a white European population. We did a GWAS in 234 European adults with any non-chemotherapy drug-induced agranulocytosis (absolute neutrophil count ≤0·5 × 10(9)/L [≤500/μL]) and 5170 population controls. 39 of the 234 patients had agranulocytosis that was induced by antithyroid drugs (thiamazole [methimazole], carbimazole, or propylthiouracil). After imputation and HLA allele prediction,

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • absolute neutrophil count if on antithyroid drugs Moderate

    Agranulocytosis develops rapidly; risk carriers require close white blood cell surveillance

    Get baseline CBC before therapy; repeat every 1-2 weeks for the first 3 months of treatment

Discuss with your doctor

  • antithyroid drug risk with physician Moderate

    rs114291795 carriers have 3.57-fold increased risk of agranulocytosis with antithyroid drugs

    Before starting thiamazole, carbimazole, or propylthiouracil, inform your physician of this genetic finding

Drug interactions

  • radioiodine or thyroidectomy over antithyroid drugs Moderate

    Carriers have substantially elevated agranulocytosis risk with antithyroid drugs; surgery/radioiodine avoid this risk

    Discuss with endocrinologist as alternative first-line treatments for hyperthyroidism