rs11422097 - ABLIM3
Magnitude 4.5 · 1 study on file
Reported associations
-
Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function - Unknown journal (n.d.) · Unknown authors · PubMed 39927731
ABSTRACT: Abstract The rising prevalence of chronic kidney disease (CKD), affecting an estimated 37 million adults in the United States, presents a significant global health challenge. CKD is typically assessed using estimated Glomerular Filtration Rate (eGFR), which incorporates serum levels of biomarkers such as creatinine and cystatin C. However, these biomarkers do not directly measure kidney function; their elevation in CKD results from diminished glomerular filtration. Genome-wide association studies (GWAS) based on eGFR formulas using creatinine (eGFRcre) or cystatin C (eGFRcys) have identified distinct non-overlapping loci, raising questions about whether these loci govern kidney function or biomarker metabolism. In this study, we show that GWAS on creatinine and cystatin C levels
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Personalized kidney disease prevention strategy Moderate
Genetic predisposition to reduced baseline kidney function warrants individualized discussion of modifiable risk factors and preventive measures.
Discuss with primary care provider or nephrologist at next visit
Screening
-
Annual kidney function panel Moderate
Strong genetic association with reduced kidney function; regular monitoring enables early detection and intervention if decline occurs.
Annual eGFR, creatinine, and cystatin C testing starting at age 30