Expressive

rs114218421 - KANK1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic exercise Moderate

    Physical activity improves liver function and metabolic health, which improves GGT levels

    Target 150 minutes of moderate-intensity aerobic exercise per week

    • GWAS_CATALOG:40436827

Lifestyle

  • Limit alcohol consumption Moderate

    Alcohol directly elevates GGT levels; limitation may help manage GGT in genetically predisposed individuals

    Discuss safe alcohol limits with healthcare provider; consider moderation or avoidance

    • GWAS_CATALOG:40436827

Screening

  • Gamma-glutamyl transferase (GGT) level Moderate

    Genetic variant associated with elevated GGT levels, a marker of liver function and oxidative stress

    Obtain baseline GGT level if not recently measured; repeat annually

    • GWAS_CATALOG:40436827